Ontology highlight
ABSTRACT:
SUBMITTER: Magdy T
PROVIDER: S-EPMC8642268 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Magdy Tarek T Jiang Zhengxin Z Jouni Mariam M Fonoudi Hananeh H Lyra-Leite Davi D Jung Gwanghyun G Romero-Tejeda Marisol M Kuo Hui-Hsuan HH Fetterman K Ashley KA Gharib Mennat M Burmeister Brian T BT Zhao Mingming M Sapkota Yadav Y Ross Colin J CJ Carleton Bruce C BC Bernstein Daniel D Burridge Paul W PW
Cell stem cell 20210915 12
Doxorubicin is an anthracycline chemotherapy agent effective in treating a wide range of malignancies, but its use is limited by dose-dependent cardiotoxicity. A recent genome-wide association study identified a SNP (rs2229774) in retinoic acid receptor-γ (RARG) as statistically associated with increased risk of anthracycline-induced cardiotoxicity. Here, we show that human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from patients with rs2229774 and who suffered doxorubicin- ...[more]