Dataset Information

Sexual differences in age-dependent survival and life span of adults in a natural butterfly population.

ABSTRACT: Adult survival and longevity in insects are key life-history traits, but their variation between sexes and individuals in natural populations is largely unexplored. Sexual divergence in senescence, the decline in survival with age is also poorly understood. Based on an intensive mark-recapture dataset of the butterfly Polyommatus daphnis, we aimed to assess whether adult survival is age-dependent, and to estimate life span distribution and abundance of males and females using Cormack-Jolly-Seber and Jolly-Seber models. Female survival slightly increased with date of emergence and slightly decreased with age, while male survival considerably declined with age. Mean life span of females (12.7 days) was ~50% higher than that of males (8.5 days), but two times higher if only the oldest 5% of each sex was considered (39 vs.19 days). Abundance of females (358?±?14) and males (359?±?11) was similar, but peak abundance of males preceded that of females by 11 days. Our results suggest that senescence is much more rapid in males than in females in this butterfly, which is in agreement with sexual selection theory. We also conclude that estimating life span distributions provides much more valuable information on the demography of natural populations than simply reporting the mean life span.

SUBMITTER: Sielezniew M

PROVIDER: S-EPMC7316833 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Sexual differences in age-dependent survival and life span of adults in a natural butterfly population.

Sielezniew Marcin M Kostro-Ambroziak Agata A Kőrösi Ádám Á

Scientific reports 20200625 1

Adult survival and longevity in insects are key life-history traits, but their variation between sexes and individuals in natural populations is largely unexplored. Sexual divergence in senescence, the decline in survival with age is also poorly understood. Based on an intensive mark-recapture dataset of the butterfly Polyommatus daphnis, we aimed to assess whether adult survival is age-dependent, and to estimate life span distribution and abundance of males and females using Cormack-Jolly-Seber ...[more]

PMID: 32587296

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Project description:BACKGROUND: Growing evidence suggests that epigenetic mechanisms of gene regulation may play a role in susceptibilities to specific toxicities and adverse drug reactions. MiRNAs in particular have been shown to be important regulators in cancer and other diseases and show promise as predictive biomarkers for diagnosis and prognosis. In this study, we characterized the global kidney miRNA expression profile in untreated male and female F344 rats throughout the life span. These findings were correlated with sex-specific susceptibilities to adverse renal events, such as male-biased renal fibrosis and inflammation in old age. METHODS: Kidney miRNA expression was examined in F344 rats at 2, 5, 6, 8, 15, 21, 78, and 104 weeks of age in both sexes using Agilent miRNA microarrays. Differential expression was determined using filtering criteria of ?1.5 fold change and ANOVA or pairwise t-test (FDR <5%) to determine significant age and sex effects, respectively. Pathway analysis software was used to investigate the possible roles of these target genes in age- and sex-specific differences. RESULTS: Three hundred eleven miRNAs were found to be expressed in at least one age and sex. Filtering criteria revealed 174 differentially expressed miRNAs in the kidney; 173 and 34 miRNAs exhibiting age and sex effects, respectively. Principal component analysis revealed age effects predominated over sex effects, with 2-week miRNA expression being much different from other ages. No significant sexually dimorphic miRNA expression was observed from 5 to 8 weeks, while the most differential expression (13 miRNAs) was observed at 21 weeks. Potential target genes of these differentially expressed miRNAs were identified. CONCLUSIONS: The expression of 56% of detected renal miRNAs was found to vary significantly with age and/or sex during the life span of F344 rats. Pathway analysis suggested that 2-week-expressed miRNAs may be related to organ and cellular development and proliferation pathways. Male-biased miRNA expression at older ages correlated with male-biased renal fibrosis and mononuclear cell infiltration. These miRNAs showed high representation in renal inflammation and nephritis pathways, and included miR-214, miR-130b, miR-150, miR-223, miR-142-5p, miR-185, and miR-296*. Analysis of kidney miRNA expression throughout the rat life span will improve the use of current and future renal biomarkers and inform our assessments of kidney injury and disease.

Project description:BackgroundPhysiological factors such as age and sex have been shown to be risk factors for adverse effects in the liver, including liver diseases and drug-induced liver injury. Previously, we have reported age- and sex-related significant differences in hepatic basal gene expression in rats during the life span that may be related to susceptibility to such adverse effects. However, the underlying mechanisms of the gene expression changes were not fully understood. In recent years, increasing evidence for epigenetic mechanisms of gene regulation has fueled interest in the role of microRNAs (miRNAs) in toxicogenomics and biomarker discovery. We therefore proposed that significant age and sex differences exist in baseline liver miRNA expression, and that comprehensive profiling of miRNAs will provide insights into the epigenetic regulation of gene expression in rat liver.MethodsTo address this, liver tissues from male and female F344 rats were examined at 2, 5, 6, 8, 15, 21, 52, 78, and 104 weeks of age for the expression of 677 unique miRNAs. Following data processing, predictive pathway analysis was performed on selected miRNAs that exhibited prominent age and/or sex differences in expression.ResultsOf the 314 miRNAs found to be expressed, 214 were differentially expressed; 65 and 212 miRNAs showed significant (false discovery rate (FDR) <5% and ≥1.5-fold change) sex- and age-related differences in expression, respectively. Thirty-eight miRNAs showed 2-week-specific expression, of which 31 miRNAs were found to be encoded within the Dlk1-Dio3 cluster located on chromosome 6. This cluster has been associated with tissue proliferation and differentiation, and liver energy homeostasis in postnatal development. Predictive pathway analysis linked sex-biased miRNA expression with sexually dimorphic molecular functions and toxicological functions that may reflect sex differences in hepatic physiology and disease. The expression of miRNAs (miR-18a, miR-99a, and miR-203, miR-451) was also found to associate with specific sexually dimorphic hepatic histopathology. The expression of miRNAs involved in regulating cell death, cell proliferation, and cell cycle was found to change as the rats matured from adult to old age.ConclusionsOverall, significant age- and sex-related differences in liver miRNA expression were identified and linked to histopathological findings and predicted functional pathways that may underlie susceptibilities to liver toxicity and disease.

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Sexual differences in age-dependent survival and life span of adults in a natural butterfly population.

Publications

Sexual differences in age-dependent survival and life span of adults in a natural butterfly population.

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