Ontology highlight
ABSTRACT:
SUBMITTER: Stieler M
PROVIDER: S-EPMC7317430 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Stieler Martin M Büchold Christian C Schmitt Marisa M Heine Andreas A Hils Martin M Pasternack Ralf R Klebe Gerhard G
ChemMedChem 20200407 10
Blood coagulation factor XIII (FXIII, F13) is considered to be a promising target for anticoagulants with reduced bleeding risk because of its unique position in the coagulation cascade downstream of thrombin. However, until now, no potent drug addressing FXIII has been available, indeed no compound has even entered clinical trials yet. In 2013, we published the co-crystal structure of FXIII in the active state (FXIIIa°), thereby providing a detailed map of the active site for the rational desig ...[more]