Ontology highlight
ABSTRACT:
SUBMITTER: Min HS
PROVIDER: S-EPMC7317551 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Min Hyun Su HS Kim Hyun Jin HJ Naito Mitsuru M Ogura Satomi S Toh Kazuko K Hayashi Kotaro K Kim Beob Soo BS Fukushima Shigeto S Anraku Yasutaka Y Miyata Kanjiro K Kataoka Kazunori K
Angewandte Chemie (International ed. in English) 20200306 21
Current antisense oligonucleotide (ASO) therapies for the treatment of central nervous system (CNS) disorders are performed through invasive administration, thereby placing a major burden on patients. To alleviate this burden, we herein report systemic ASO delivery to the brain by crossing the blood-brain barrier using glycemic control as an external trigger. Glucose-coated polymeric nanocarriers, which can be bound by glucose transporter-1 expressed on the brain capillary endothelial cells, are ...[more]