Ontology highlight
ABSTRACT:
SUBMITTER: Ramadan S
PROVIDER: S-EPMC7318065 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Ramadan Sherif S Li Tianlu T Yang Weizhun W Zhang Jicheng J Rashidijahanabad Zahra Z Tan Zibin Z Parameswaran Narayanan N Huang Xuefei X
ACS central science 20200601 6
Bikunin, a chondroitin sulfate (CS) proteoglycan clinically used to treat acute inflammation and sepsis, contains a CS chain with more than 20 monosaccharide units. To understand the function of the CS chain of bikunin, synthesis of long CS chains is needed. After exploring multiple glycosylation approaches and protective group chemistry, we report herein the successful generation of the longest CS chain to date (24-mer) in an excellent overall yield on a multi-mg scale. The anti-inflammatory ac ...[more]