Ontology highlight
ABSTRACT:
SUBMITTER: Dearborn AD
PROVIDER: S-EPMC7319042 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Dearborn Altaira D AD Eren Elif E Watts Norman R NR Palmer Ira W IW Kaufman Joshua D JD Steven Alasdair C AC Wingfield Paul T PT
Structure (London, England : 1993) 20180712 9
HIV-1 Rev protein mediates nuclear export of unspliced and partially spliced viral RNAs for production of viral genomes and structural proteins. Rev assembles on a 351-nt Rev response element (RRE) within viral transcripts and recruits host export machinery. Small (<40-nt) RNA aptamers that compete with the RRE for Rev binding inhibit HIV-1 viral replication. We determined the X-ray crystal structure of a potential anti-HIV-1 aptamer that binds Rev with high affinity (K<sub>d</sub> = 5.9 nM). Th ...[more]