Ontology highlight
ABSTRACT:
SUBMITTER: Rydenfelt M
PROVIDER: S-EPMC7319438 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Nucleic acids research 20200701 W1
Extracting signalling pathway activities from transcriptome data is important to infer mechanistic origins of transcriptomic dysregulation, for example in disease. A popular method to do so is by enrichment analysis of signature genes in e.g. differentially regulated genes. Previously, we derived signatures for signalling pathways by integrating public perturbation transcriptome data and generated a signature database called SPEED (Signalling Pathway Enrichment using Experimental Datasets), for ...[more]