Ontology highlight
ABSTRACT:
SUBMITTER: Pockrandt C
PROVIDER: S-EPMC7320602 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Pockrandt Christopher C Alzamel Mai M Iliopoulos Costas S CS Reinert Knut K
Bioinformatics (Oxford, England) 20200601 12
<h4>Motivation</h4>Computing the uniqueness of k-mers for each position of a genome while allowing for up to e mismatches is computationally challenging. However, it is crucial for many biological applications such as the design of guide RNA for CRISPR experiments. More formally, the uniqueness or (k, e)-mappability can be described for every position as the reciprocal value of how often this k-mer occurs approximately in the genome, i.e. with up to e mismatches.<h4>Results</h4>We present a fast ...[more]