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Five New Pregnane Glycosides from Gymnema sylvestre and Their ?-Glucosidase and ?-Amylase Inhibitory Activities.


ABSTRACT: Gymnema sylvestre, a medicinal plant, has been used in Indian ayurvedic traditional medicine for the treatment of diabetes. Phytochemical investigation of Gymnema sylvestre led to the isolation of five new pregnane glycosides, gymsylosides A-E (1-5) and four known oleanane saponins, 3?-O-?-D-glucopyranosyl (1?6)-?-D-glucopyranosyl oleanolic acid 28-O-?-D-glucopyranosyl ester (6), gymnemoside-W1 (7), 3?-O-?-D-xylopyranosyl-(1?6)-?-D- glucopyranosyl-(1?6)-?-D-glucopyranosyl oleanolic acid 28-O-?-D-glucopyranosyl ester (8), and alternoside XIX (9). Their structures were identified based on spectroscopic evidence and comparison with those reported in the literature. All compounds were evaluated for their ?-glucosidase and ?-amylase inhibitory activities. Compounds 2-4 showed significant ?-amylase inhibitory activity, with IC50 values ranging from 113.0 to 176.2 µM.

SUBMITTER: Kiem PV 

PROVIDER: S-EPMC7321224 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Five New Pregnane Glycosides from <i>Gymnema sylvestre</i> and Their α-Glucosidase and α-Amylase Inhibitory Activities.

Kiem Phan Van PV   Yen Duong Thi Hai DTH   Hung Nguyen Van NV   Nhiem Nguyen Xuan NX   Tai Bui Huu BH   Trang Do Thi DT   Yen Pham Hai PH   Ngoc Tran Minh TM   Minh Chau Van CV   Park SeonJu S   Lee Jae Hyuk JH   Kim Sun Yeou SY   Kim Seung Hyun SH  

Molecules (Basel, Switzerland) 20200528 11


<i>Gymnema sylvestre</i>, a medicinal plant, has been used in Indian ayurvedic traditional medicine for the treatment of diabetes. Phytochemical investigation of <i>Gymnema sylvestre</i> led to the isolation of five new pregnane glycosides, gymsylosides A-E (<b>1</b>-<b>5</b>) and four known oleanane saponins, 3β-<i>O-</i>β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl oleanolic acid 28-<i>O-</i>β-D-glucopyranosyl ester (<b>6</b>), gymnemoside-W1 (<b>7</b>), 3β-<i>O-</i>β-D-xylopyranosyl-(1→6)-β-D-  ...[more]

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