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An Efficient Greener Approach for N-Acylation of Amines in Water Using Benzotriazole Chemistry.

ABSTRACT: A straightforward, mild and cost-efficient synthesis of various arylamides in water was accomplished using versatile benzotriazole chemistry. Acylation of various amines was achieved in water at room temperature as well as under microwave irradiation. The developed protocol unfolds the synthesis of amino acid aryl amides, drug conjugates and benzimidazoles. The environmentally friendly synthesis, short reaction time, simple workup, high yields, mild conditions and free of racemization are the key advantages of this protocol.

SUBMITTER: Ibrahim TS

PROVIDER: S-EPMC7321353 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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An Efficient Greener Approach for <i>N</i>-Acylation of Amines in Water Using Benzotriazole Chemistry.

Ibrahim Tarek S TS Seliem Israa A IA Panda Siva S SS Al-Mahmoudy Amany M M AMM Abdel-Samii Zakaria K M ZKM Alhakamy Nabil A NA Asfour Hani Z HZ Elagawany Mohamed M

Molecules (Basel, Switzerland) 20200528 11

A straightforward, mild and cost-efficient synthesis of various arylamides in water was accomplished using versatile benzotriazole chemistry. Acylation of various amines was achieved in water at room temperature as well as under microwave irradiation. The developed protocol unfolds the synthesis of amino acid aryl amides, drug conjugates and benzimidazoles. The environmentally friendly synthesis, short reaction time, simple workup, high yields, mild conditions and free of racemization are the ke ...[more]

PMID: 32481504

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