Deletion of Mouse Setd4 Promotes the Recovery of Hematopoietic Failure.

ABSTRACT:

Purpose

Acquired hematopoietic failure is commonly caused by therapeutic and accidental exposure of the bone marrow (BM) to toxic agents. Efficient recovery from BM failure is dictated not only by the intrinsic sensitivity and proliferation capacity of the hematopoietic stem and progenitor cells but also by the BM environment niche. Identification of genetic factors that improve recovery from hematopoietic failure is essential. Vertebrate SETD4 is a poorly characterized and putatively nonhistone methyltransferase. This study aims to identify the roles of SETD4 in BM recovery.

Methods and materials

An inducible SETD4 knockout mouse model (Setd4^flox/flox;Rosa26-CreERT2⁺) was used. Adult sex-matched littermates were treated with tamoxifen to induce Setd4 d

SUBMITTER: Feng X 

PROVIDER: S-EPMC7321877 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature