Ontology highlight
ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC7322087 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20200609 25
Phosphorothioate (PT) DNA modifications-in which a nonbonding phosphate oxygen is replaced with sulfur-represent a widespread, horizontally transferred epigenetic system in prokaryotes and have a highly unusual property of occupying only a small fraction of available consensus sequences in a genome. Using <i>Salmonella enterica</i> as a model, we asked a question of fundamental importance: How do the PT-modifying DndA-E proteins select their G<sub>PS</sub>AAC/G<sub>PS</sub>TTC targets? Here, we ...[more]