Ontology highlight
ABSTRACT:
SUBMITTER: Huang D
PROVIDER: S-EPMC7322801 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Huang Dachuan D Song Tammy Linlin TL Nairismägi Maarja-Liisa ML Laurensia Yurike Y Pang Wan-Lu WL Zhe Daryl Cheah Ming DCM Wong Esther Kam Yin EKY Wijaya Giovani Giovani-Clarest GG Tan Jing J Tan Sze Huey SH Lim Jing-Quan JQ Chia Burton Kuan Hui BKH Chan Jason Yongsheng JY Tang Tiffany Pooi Ling TPL Somasundaram Nagavalli N Cheng Chee Leong CL Politz Oliver O Liu Ningshu N Lim Soon Thye ST Ong Choon Kiat CK
British journal of haematology 20200131 4
Peripheral T-cell lymphomas (PTCL) and natural killer (NK)/T-cell lymphomas (NKTCL) are a heterogeneous group of aggressive malignancies with dismal outcomes and limited treatment options. While the phosphatidylinositol 3-kinase (PIK3) pathway has been shown to be highly activated in many B-cell lymphomas, its therapeutic relevance in PTCL and NKTCL remains unclear. The aim of this study is to investigate the expression of PIK3 and phosphatase and tensin homolog (PTEN) in these subtypes of lymph ...[more]