Quantitative evaluation of interim positron emission tomography in peripheral T-cell lymphoma.

ABSTRACT:

Background

Interim [¹⁸F]fluoro-deoxyglucose-positron emission tomography predicts outcome in peripheral T-cell lymphoma (PTCL). We compared two quantitative evaluation methods.

Methods

Interim scans from 43 patients with anaplastic lymphoma kinase-negative PTCL from the 'Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin Lymphomas' trial were re-analyzed by qPET (relating residual lymphoma-related uptake to liver uptake) and ∆SUV_max (relating interim scan to baseline scan). The endpoint was progression-free survival.

Results

qPET and ∆SUV_max were closely correlated (Pearson's r = 0.627). Up to the 60^th percentile of values ranked by increasing residual activity, the positive predictive value for progressio

SUBMITTER: Kurch L 

PROVIDER: S-EPMC8440745 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature