Intraoperative hypotension is associated with shortened overall survival after lung cancer surgery.

ABSTRACT: BACKGROUND:Intraoperative hypotension is associated with increased morbidity and mortality after surgery. We hypothesized that intraoperative hypotension might also be associated with worse long-term survival after cancer surgery. Herein, we analyzed the correlation between intraoperative hyper-/hypotension and overall survival after lung cancer surgery. METHODS:In this retrospective cohort study, 676 patients who received lung cancer surgery between January 1, 2006 and December 31, 2009 were reviewed. Intraoperative hyper- and hypotension were defined according to their correlation with long-term survival. The primary endpoint was overall survival. The association between episodes of intraoperative hyper-/hypotension and overall survival was analyzed with multivariable Cox proportional hazard models. RESULTS:Long-term follow-ups were completed in 515 patients with a median duration of 5.2?years. The estimated 5-year survival rates were 66.5, 61.3, 56.5, and 41.2% in patients with only hypertension (systolic blood pressure?>?140?mmHg for ?5?min), with both hyper- and hypotension (systolic blood pressure?

SUBMITTER: Huang WW 

PROVIDER: S-EPMC7322881 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature