Ontology highlight
ABSTRACT:
SUBMITTER: Pashev A
PROVIDER: S-EPMC7323625 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Pashev Aleksandar A Burdzhiev Nikola N Stanoeva Elena E
Beilstein journal of organic chemistry 20200624
The Castagnoli-Cushman reaction of 3,4-dihydroisoquinolines with glutaric anhydride, its oxygen and sulfur analogues was investigated as a one-step approach to the benzo[<i>a</i>]quinolizidine system and its heterocyclic analogs. An extension towards the pyrrolo[2,1-<i>a</i>]isoquinoline system was achieved with the use of succinic anhydride. The results are evidence of an unexplored method for the access of the aforementioned tricyclic annelated systems incorporating a bridgehead nitrogen atom. ...[more]