Dataset Information

Metabolic Changes in Chronic Hepatitis C Patients Who Carry IFNL4-?G and Achieve Sustained Virologic Response With Direct-Acting Antiviral Therapy.

ABSTRACT:

Background

Clearance of hepatitis C virus (HCV) results in rapid changes in metabolic parameters early in direct-acting antiviral (DAA) therapy. Long-term changes after sustained virologic response (SVR) remain unknown.

Methods

We investigated longitudinal changes in metabolic and inflammatory outcomes in chronic hepatitis C (CHC) patients: low-density lipoprotein (LDL), high-density lipoprotein, triglycerides, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) using a general linear model for repeated measurements at 5 clinical time points and by human immunodeficiency virus (HIV) coinfection and IFNL4 genotype.

Results

The mean LDL increased markedly during DAA therapy (pre-DAA, 86.6 to DAA, 107.4 mg/dL; P < .0001), but then it decreased to 97.7 mg/dL by post-SVR year 1 (P < .001 compared with DAA; P = .0013 compared with SVR). In patients who carry the IFNL4-?G allele, mean LDL increased during treatment, then decreased at post-SVR year 1; however, in patients with TT/TT, genotype did not change during and after DAA treatment. The mean ALT and AST normalized rapidly between pre-DAA and DAA, whereas only mean ALT continued to decrease until post-SVR. Metabolic and inflammatory outcomes were similar by HIV-coinfection status.

Conclusions

Changes in LDL among CHC patients who achieved SVR differed by IFNL4 genotype, which implicates the interferon-?4 protein in metabolic changes observed in HCV-infected patients.

SUBMITTER: Emmanuel B

PROVIDER: S-EPMC7325530 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Publications

Metabolic Changes in Chronic Hepatitis C Patients Who Carry IFNL4-ΔG and Achieve Sustained Virologic Response With Direct-Acting Antiviral Therapy.

Emmanuel Benjamin B El-Kamary Samer S SS Magder Laurence S LS Stafford Kristen A KA Charurat Man E ME Chairez Cheryl C McLaughlin Mary M Hadigan Colleen C Prokunina-Olsson Ludmila L O'Brien Thomas R TR Masur Henry H Kottilil Shyam S

The Journal of infectious diseases 20200101 1

<h4>Background</h4>Clearance of hepatitis C virus (HCV) results in rapid changes in metabolic parameters early in direct-acting antiviral (DAA) therapy. Long-term changes after sustained virologic response (SVR) remain unknown.<h4>Methods</h4>We investigated longitudinal changes in metabolic and inflammatory outcomes in chronic hepatitis C (CHC) patients: low-density lipoprotein (LDL), high-density lipoprotein, triglycerides, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) u ...[more]

PMID: 31504644

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