Generation of a glycosylated asparagine residue through chemoselective acylation of a glycosylhydrazide.
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ABSTRACT: Herein, we report the first selective anomeric N-acylation of a glycosylhydrazide. We show that this transformation can be harnessed to generate amino acid building blocks including FmocAsn(GlcNAc)OH (1), a residue that has been previously shown to be a competent reagent in the solid-phase peptide synthesis of N-linked glycopeptides.
SUBMITTER: Rykaczewski KA
PROVIDER: S-EPMC7325706 | biostudies-literature |
REPOSITORIES: biostudies-literature
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