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Generation of a glycosylated asparagine residue through chemoselective acylation of a glycosylhydrazide.


ABSTRACT: Herein, we report the first selective anomeric N-acylation of a glycosylhydrazide. We show that this transformation can be harnessed to generate amino acid building blocks including FmocAsn(GlcNAc)OH (1), a residue that has been previously shown to be a competent reagent in the solid-phase peptide synthesis of N-linked glycopeptides.

SUBMITTER: Rykaczewski KA 

PROVIDER: S-EPMC7325706 | biostudies-literature |

REPOSITORIES: biostudies-literature

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