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Metabolomic Analysis of Aspergillus niger Isolated From the International Space Station Reveals Enhanced Production Levels of the Antioxidant Pyranonigrin A.


ABSTRACT: Secondary metabolite (SM) production in Aspergillus niger JSC-093350089, isolated from the International Space Station (ISS), is reported, along with a comparison to the experimentally established strain ATCC 1015. The analysis revealed enhanced production levels of naphtho-?-pyrones and therapeutically relevant SMs, including bicoumanigrin A, aurasperones A and B, and the antioxidant pyranonigrin A. Genetic variants that may be responsible for increased SM production levels in JSC-093350089 were identified. These findings include INDELs within the predicted promoter region of flbA, which encodes a developmental regulator that modulates pyranonigrin A production via regulation of Fum21. The pyranonigrin A biosynthetic gene cluster was confirmed in A. niger, which revealed the involvement of a previously undescribed gene, pyrE, in its biosynthesis. UVC sensitivity assays enabled characterization of pyranonigrin A as a UV resistance agent in the ISS isolate.

SUBMITTER: Romsdahl J 

PROVIDER: S-EPMC7326050 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Metabolomic Analysis of <i>Aspergillus niger</i> Isolated From the International Space Station Reveals Enhanced Production Levels of the Antioxidant Pyranonigrin A.

Romsdahl Jillian J   Blachowicz Adriana A   Chiang Yi-Ming YM   Venkateswaran Kasthuri K   Wang Clay C C CCC  

Frontiers in microbiology 20200521


Secondary metabolite (SM) production in <i>Aspergillus niger</i> JSC-093350089, isolated from the International Space Station (ISS), is reported, along with a comparison to the experimentally established strain ATCC 1015. The analysis revealed enhanced production levels of naphtho-γ-pyrones and therapeutically relevant SMs, including bicoumanigrin A, aurasperones A and B, and the antioxidant pyranonigrin A. Genetic variants that may be responsible for increased SM production levels in JSC-093350  ...[more]

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