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Immunotherapy For Ovarian Cancer: Recent Advances And Combination Therapeutic Approaches.

ABSTRACT: Epithelial ovarian cancer (EOC) is the most lethal gynaecological cancer. Although many advances have been made in therapeutic strategies, the global standard of care still remains radical surgery plus chemotherapy, but new scenarios need to be explored to improve survival. The role of immunotherapy in EOC treatment is controversial. Results obtained from studies evaluating immunotherapy are contradictory: in particular data on survival are not as good as expected when immunotherapy was administered alone, and other data are still immature. Thus, significant efforts must be devoted to finding new strategies for the use of immunotherapy. The aim of this paper is to review the most recent findings of the use of immunotherapy in ovarian cancer, with a particular focus on combination approaches.

SUBMITTER: Palaia I 

PROVIDER: S-EPMC7326187 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Immunotherapy For Ovarian Cancer: Recent Advances And Combination Therapeutic Approaches.

Palaia Innocenza I   Tomao Federica F   Sassu Carolina Maria CM   Musacchio Lucia L   Benedetti Panici Pierluigi P  

OncoTargets and therapy 20200626

Epithelial ovarian cancer (EOC) is the most lethal gynaecological cancer. Although many advances have been made in therapeutic strategies, the global standard of care still remains radical surgery plus chemotherapy, but new scenarios need to be explored to improve survival. The role of immunotherapy in EOC treatment is controversial. Results obtained from studies evaluating immunotherapy are contradictory: in particular data on survival are not as good as expected when immunotherapy was administ  ...[more]

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