Ontology highlight
ABSTRACT:
SUBMITTER: Triki M
PROVIDER: S-EPMC7326293 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Cell reports 20200601 12
Cancer cells display an increased plasticity in their lipid metabolism, which includes the conversion of palmitate to sapienate via the enzyme fatty acid desaturase 2 (FADS2). We find that FADS2 expression correlates with mammalian target of rapamycin (mTOR) signaling and sterol regulatory element-binding protein 1 (SREBP-1) activity across multiple cancer types and is prognostic in some cancer types. Accordingly, activating mTOR signaling by deleting tuberous sclerosis complex 2 (Tsc2) or overe ...[more]