Ontology highlight
ABSTRACT:
SUBMITTER: Menuet C
PROVIDER: S-EPMC7326498 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Menuet Clément C Connelly Angela A AA Bassi Jaspreet K JK Melo Mariana R MR Le Sheng S Kamar Jessica J Kumar Natasha N NN McDougall Stuart J SJ McMullan Simon S Allen Andrew M AM
eLife 20200615
Heart rate and blood pressure oscillate in phase with respiratory activity. A component of these oscillations is generated centrally, with respiratory neurons entraining the activity of pre-sympathetic and parasympathetic cardiovascular neurons. Using a combination of optogenetic inhibition and excitation in vivo and in situ in rats, as well as neuronal tracing, we demonstrate that preBötzinger Complex (preBötC) neurons, which form the kernel for inspiratory rhythm generation, directly modulate ...[more]