Dataset Information

Quantification of ¹¹C-PIB kinetics in cardiac amyloidosis.

ABSTRACT:

Background

The purpose of this work was to determine the optimal tracer kinetic model of ¹¹C-PIB and to validate the use of the simplified methods retention index (RI) and standardized uptake value (SUV) for quantification of cardiac ¹¹C-PIB uptake in amyloidosis.

Methods and results

Single-tissue, reversible and irreversible two-tissue models were fitted to data from seven cardiac amyloidosis patients who underwent ¹¹C-PIB PET scans and arterial blood sampling for measurement of blood radioactivity and metabolites. The irreversible two-tissue model (2Tirr) best described cardiac ¹¹C-PIB uptake. RI and SUV showed high correlation with the rate of irreversible binding (K_i) from the 2Tirr model (r^2?=0.95 and r^2?=0.94). Retrospective data from 10 amyloidosis patients and 5 healthy controls were analyzed using RI, SUV, as well as compartment modelling with a population-average metabolite correction. All measures were higher in amyloidosis patients than in healthy controls (p=.001), but with an overlap between groups for K_i.

Conclusion

An irreversible two-tissue model best describes the ¹¹C-PIB uptake in cardiac amyloidosis. RI and SUV correlate well with K_i from the 2Tirr model. RI and SUV discriminate better between amyloidosis patients and controls than K_i based on population-average metabolite correction.

SUBMITTER: Kero T

PROVIDER: S-EPMC7326793 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Publications

Quantification of <sup>11</sup>C-PIB kinetics in cardiac amyloidosis.

Kero Tanja T Sörensen Jens J Antoni Gunnar G Wilking Helena H Carlson Kristina K Vedin Ola O Rosengren Sara S Wikström Gerhard G Lubberink Mark M

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20180723 3

<h4>Background</h4>The purpose of this work was to determine the optimal tracer kinetic model of <sup>11</sup>C-PIB and to validate the use of the simplified methods retention index (RI) and standardized uptake value (SUV) for quantification of cardiac <sup>11</sup>C-PIB uptake in amyloidosis.<h4>Methods and results</h4>Single-tissue, reversible and irreversible two-tissue models were fitted to data from seven cardiac amyloidosis patients who underwent <sup>11</sup>C-PIB PET scans and arterial b ...[more]

PMID: 30039218

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Dataset Information

Quantification of ¹¹C-PIB kinetics in cardiac amyloidosis.

Background

Methods and results

Conclusion

Publications

Quantification of <sup>11</sup>C-PIB kinetics in cardiac amyloidosis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Quantification of 11C-PIB kinetics in cardiac amyloidosis.

Background

Methods and results

Conclusion

Publications

Quantification of <sup>11</sup>C-PIB kinetics in cardiac amyloidosis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Quantification of ¹¹C-PIB kinetics in cardiac amyloidosis.