DPD Quantification in Cardiac Amyloidosis: A Novel Imaging Biomarker.

ABSTRACT:

Objectives

To assess whether single-photon emission computed tomography (SPECT/CT) quantification of bone scintigraphy would improve diagnostic accuracy and offer a means of quantifying amyloid burden.

Background

Transthyretin-related cardiac amyloidosis is common and can be diagnosed noninvasively using bone scintigraphy; interpretation, however, relies on planar images. SPECT/CT imaging offers 3-dimensional visualization.

Methods

This was a single-center, retrospective analysis of ^99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scans reported using the Perugini grading system (0 = negative; 1 to 3 = increasingly positive). Conventional planar quantification techniques (heart/contralateral lung, and heart/whole-body retention ratios) were performe

SUBMITTER: Scully PR 

PROVIDER: S-EPMC7264710 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature