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1,2,3-Triazole ?-lactam conjugates as antimicrobial agents.


ABSTRACT: A convenient and efficient synthesis of new triazole ?-lactam conjugates using click chemistry is described. ?-lactam 15 and 16 were prepared using cycloaddition strategy and propargylated at N-1 to afford compounds 17 and 18. Cu-catalyzed click reaction of these ?-lactams 17 and 18 with different aryl azides provided 1,2,3-triazole conjugates 6 and 7, respectively. The products were fully characterized spectroscopically and tested against Gram-(+) and Gram-(-) bacteria. Compound 7a and 7c were found to be most active.

SUBMITTER: Kaur R 

PROVIDER: S-EPMC7327255 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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1,2,3-Triazole β-lactam conjugates as antimicrobial agents.

Kaur Rajneesh R   Singh Raman R   Kumar Antresh A   Kaur Satvinder S   Priyadarshi Nitesh N   Singhal Nitin Kumar NK   Singh Kuldeep K  

Heliyon 20200627 6


A convenient and efficient synthesis of new triazole β-lactam conjugates using click chemistry is described. β-lactam <b>15</b> and <b>16</b> were prepared using cycloaddition strategy and propargylated at <i>N</i>-1 to afford compounds <b>17</b> and <b>18</b>. Cu-catalyzed click reaction of these β-lactams <b>17</b> and <b>18</b> with different aryl azides provided 1,2,3-triazole conjugates <b>6</b> and <b>7</b>, respectively. The products were fully characterized spectroscopically and tested a  ...[more]

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