Ontology highlight
ABSTRACT:
SUBMITTER: Kaur R
PROVIDER: S-EPMC7327255 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Kaur Rajneesh R Singh Raman R Kumar Antresh A Kaur Satvinder S Priyadarshi Nitesh N Singhal Nitin Kumar NK Singh Kuldeep K
Heliyon 20200627 6
A convenient and efficient synthesis of new triazole β-lactam conjugates using click chemistry is described. β-lactam <b>15</b> and <b>16</b> were prepared using cycloaddition strategy and propargylated at <i>N</i>-1 to afford compounds <b>17</b> and <b>18</b>. Cu-catalyzed click reaction of these β-lactams <b>17</b> and <b>18</b> with different aryl azides provided 1,2,3-triazole conjugates <b>6</b> and <b>7</b>, respectively. The products were fully characterized spectroscopically and tested a ...[more]