Unknown

Dataset Information

0

Metabolic Dynamics and Prediction of Gestational Age and Time to Delivery in Pregnant Women.


ABSTRACT: Metabolism during pregnancy is a dynamic and precisely programmed process, the failure of which can bring devastating consequences to the mother and fetus. To define a high-resolution temporal profile of metabolites during healthy pregnancy, we analyzed the untargeted metabolome of 784 weekly blood samples from 30 pregnant women. Broad changes and a highly choreographed profile were revealed: 4,995 metabolic features (of 9,651 total), 460 annotated compounds (of 687 total), and 34 human metabolic pathways (of 48 total) were significantly changed during pregnancy. Using linear models, we built a metabolic clock with five metabolites that time gestational age in high accordance with ultrasound (R = 0.92). Furthermore, two to three metabolites can identify when labor occurs (time to delivery within two, four, and eight weeks, AUROC ? 0.85). Our study represents a weekly characterization of the human pregnancy metabolome, providing a high-resolution landscape for understanding pregnancy with potential clinical utilities.

SUBMITTER: Liang L 

PROVIDER: S-EPMC7327522 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications


Metabolism during pregnancy is a dynamic and precisely programmed process, the failure of which can bring devastating consequences to the mother and fetus. To define a high-resolution temporal profile of metabolites during healthy pregnancy, we analyzed the untargeted metabolome of 784 weekly blood samples from 30 pregnant women. Broad changes and a highly choreographed profile were revealed: 4,995 metabolic features (of 9,651 total), 460 annotated compounds (of 687 total), and 34 human metaboli  ...[more]

Similar Datasets

2019-08-30 | ST001430 | MetabolomicsWorkbench
| S-EPMC6662791 | biostudies-literature
| S-EPMC10434204 | biostudies-literature
2013-10-08 | E-GEOD-41438 | biostudies-arrayexpress
| S-EPMC7082997 | biostudies-literature
2013-10-08 | GSE41438 | GEO
| S-EPMC3558854 | biostudies-literature
| S-EPMC9612230 | biostudies-literature
| S-EPMC9489389 | biostudies-literature
2024-12-29 | GSE255075 | GEO