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Characterization of a rare bla VIM-4 metallo-?-lactamase-producing Serratia marcescens clinical isolate in Hungary.


ABSTRACT: A carbapenem-resistant S. marcescens isolate was recovered from a patient with an inflammed pacemaker inplantation pocket from a Cardiac Surgery ward in a Hungarian University Hospital. Phenotypic tests and polymerase chain reaction (PCR) confirmed a very rare gene responsible for production of a carbapenemase ( bla VIM-4 ), which was further characterized by Sanger-sequencing. The characterization of this S. marcescens strain emphasizes the ongoing emergence of novel or rare carbapenemases. Strains expressing a weak carbapenemase like this strain might go unrecognized by routine diagnostics due to low minimum inhibitory concentrations (MICs) for the bacterial strains producing such enzymes.

SUBMITTER: Toth A 

PROVIDER: S-EPMC7327745 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Characterization of a rare <i>bla</i> <sub>VIM-4</sub> metallo-β-lactamase-producing <i>Serratia marcescens</i> clinical isolate in Hungary.

Tóth Ákos Á   Makai Attila A   Jánvári Laura L   Damjanova Ivelina I   Gajdács Márió M   Urbán Edit E  

Heliyon 20200627 6


A carbapenem-resistant <i>S. marcescens</i> isolate was recovered from a patient with an inflammed pacemaker inplantation pocket from a Cardiac Surgery ward in a Hungarian University Hospital. Phenotypic tests and polymerase chain reaction (PCR) confirmed a very rare gene responsible for production of a carbapenemase ( <b><i>bla</i></b> <sub><b>VIM-4</b></sub> ), which was further characterized by Sanger-sequencing. The characterization of this <i>S. marcescens</i> strain emphasizes the ongoing  ...[more]

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