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Alendronate loaded graphene oxide functionalized collagen sponge for the dual effects of osteogenesis and anti-osteoclastogenesis in osteoporotic rats.

ABSTRACT: Highlights•Alendronate-loading graphene oxide modified collagen sponge (Col-GO-Aln) exhibit a sustained drug delivery.•Col-GO-Aln sponge showed active anti-osteoclastogenesis and osteogenesis ability in vitro and in situ repair.•Col-GO-Aln sponge achieved a potential systemic resistance to bone loss in osteoporotic rats.

SUBMITTER: Zeng Y

PROVIDER: S-EPMC7327758 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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