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Blood neutrophil counts are associated with exacerbation frequency and mortality in COPD.


ABSTRACT: BACKGROUND:Identifying patients with COPD at increased risk of poor outcomes is challenging due to disease heterogeneity. Potential biomarkers need to be readily available in real-life clinical practice. Blood eosinophil counts are widely studied but few studies have examined the prognostic value of blood neutrophil counts (BNC). METHODS:In a large population-based COPD registry in the East of Scotland (TARDIS: Tayside Allergic and Respiratory Disease Information System), BNC were compared to measures of disease severity and mortality for up to 15?years follow-up. Potential mechanisms of disease modification by BNC were explored in a nested microbiome substudy. RESULTS:178,120 neutrophil counts were obtained from 7220 people (mean follow up 9?years) during stable disease periods. Median BNC was 5200cells/?L (IQR 4000-7000cells/?L). Mortality rates among the 34% of patients with elevated BNCs (defined as 6000-15000cells/?L) at the study start were 80% higher (14.0/100 person years v 7.8/100py, P?

SUBMITTER: Lonergan M 

PROVIDER: S-EPMC7329438 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Blood neutrophil counts are associated with exacerbation frequency and mortality in COPD.

Lonergan Mike M   Dicker Alison J AJ   Crichton Megan L ML   Keir Holly R HR   Van Dyke Melissa K MK   Mullerova Hana H   Miller Bruce E BE   Tal-Singer Ruth R   Chalmers James D JD  

Respiratory research 20200701 1


<h4>Background</h4>Identifying patients with COPD at increased risk of poor outcomes is challenging due to disease heterogeneity. Potential biomarkers need to be readily available in real-life clinical practice. Blood eosinophil counts are widely studied but few studies have examined the prognostic value of blood neutrophil counts (BNC).<h4>Methods</h4>In a large population-based COPD registry in the East of Scotland (TARDIS: Tayside Allergic and Respiratory Disease Information System), BNC were  ...[more]

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