Ontology highlight
ABSTRACT:
SUBMITTER: Zhang N
PROVIDER: S-EPMC7329491 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Zhang Nan N Di Jiabo J Wang Zaozao Z Gao Pin P Jiang Beihai B Su Xiangqian X
Cancer cell international 20200701
<h4>Background</h4>Metastasis is a major cause of failed colorectal cancer (CRC) treatment. While lung metastasis (LM) is observed in 10-15% of patients with CRC, the genetic mechanisms that cause CRC to metastasize to the lung remain unclear.<h4>Methods</h4>In this study, we employed whole exome sequencing (WES) of primary CRC tumors and matched isolated LM lesions to compare their genomic profiles. Comprehensive genomic analyses of five freshly frozen primary tumor lesions, five paired LM lesi ...[more]