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Dual Inhibition of MAPK and JAK2/STAT3 Pathways Is Critical for the Treatment of BRAF Mutant Melanoma.


ABSTRACT: Drug resistance limits the long-term efficacy of targeted drugs for melanoma. The results showed that there is a crosstalk between the MAPK and JAK2/STAT3 pathways in BRAF mutant melanoma cells. Dual inhibition of the MAPK and JAK2/STAT3 pathways can significantly inhibit the growth of BRAF mutant melanoma cells.

SUBMITTER: Zhao K 

PROVIDER: S-EPMC7330142 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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