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Moderate rate of transmitted resistance mutations to antiretrovirals and genetic diversity in newly HIV-1 patients diagnosed in Benin.


ABSTRACT: OBJECTIVE:Seventeen years after the start of the IBAARV (Beninese initiative for access to antiretrovirals), transmitted drug resistance mutations in ARV-naïve patients and HIV-1 genetic diversity were investigated in Benin. RESULTS:Drug resistance mutations were detected in (27/248; 10.9%) according to the WHO SDRM 2009 list, with a predominance of mutations directed against NNRTIs drugs (24/248; 10%). Phylogenetic and recombination analyses showed a predominance of CRF02_AG strains (165/248; 66.5%) and a high genetic diversity with five other variants and 39 URFs (15.7%) which contained portions of strains that co-circulate in Benin. Eight recent transmission chains revealed active ongoing transmission of HIV-1 strains among ARV-naïve patients. Our study showed a moderate primary drug resistance mutations rate and also provided recent data on the HIV-1 variants that circulate in Benin. Regular monitoring of primary drug resistance is required to adapt HIV-1 treatment strategies and adoption of new WHO recommendations in Benin.

SUBMITTER: Tchiakpe E 

PROVIDER: S-EPMC7330984 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Moderate rate of transmitted resistance mutations to antiretrovirals and genetic diversity in newly HIV-1 patients diagnosed in Benin.

Tchiakpe Edmond E   Keke Rene K RK   Vidal Nicole N   Ahoussinou Clément C   Sekpe Olga O   Dagba Hermione G HG   Gbaguidi Eric E   Tonoukouen Conrad C   Afangnihoun Aldric A   Bachabi Moussa M   Gangbo Flore A FA   Diop-Ndiaye Halimatou H   Toure-Kane Coumba C  

BMC research notes 20200702 1


<h4>Objective</h4>Seventeen years after the start of the IBAARV (Beninese initiative for access to antiretrovirals), transmitted drug resistance mutations in ARV-naïve patients and HIV-1 genetic diversity were investigated in Benin.<h4>Results</h4>Drug resistance mutations were detected in (27/248; 10.9%) according to the WHO SDRM 2009 list, with a predominance of mutations directed against NNRTIs drugs (24/248; 10%). Phylogenetic and recombination analyses showed a predominance of CRF02_AG stra  ...[more]

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