Ontology highlight
ABSTRACT:
SUBMITTER: Birnhuber A
PROVIDER: S-EPMC7331186 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Birnhuber Anna A Egemnazarov Bakytbek B Biasin Valentina V Bonyadi Rad Ehsan E Wygrecka Malgorzata M Olschewski Horst H Kwapiszewska Grazyna G Marsh Leigh M LM
Respiratory research 20200702 1
Inhibitors of cyclin-dependent kinases 4/6 (CDK4/6) block cell cycle progression and are commonly used for treatment of several forms of cancer. Due to their anti-proliferative mode of action, we hypothesized that palbociclib could attenuate the development of bleomycin-induced lung fibrosis. In a preclinical setting, mice were treated with bleomycin and then co-treated with or without palbociclib. Lung function, collagen deposition and pulmonary inflammation were analysed after 14 days.Bleomyci ...[more]