Ontology highlight
ABSTRACT:
SUBMITTER: Joshi H
PROVIDER: S-EPMC8998782 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Joshi Hemant H Almgren-Bell Alison A Anaya Edgar P EP Todd Elizabeth M EM Van Dyken Steven J SJ Seth Anushree A McIntire Katherine M KM Singamaneni Srikanth S Sutterwala Fayyaz F Morley Sharon C SC
Cell reports 20220301 11
Macrophage adhesion and stretching have been shown to induce interleukin (IL)-1β production, but the mechanism of this mechanotransduction remains unclear. Here we specify the molecular link between mechanical tension on tissue-resident macrophages and activation of the NLRP3 inflammasome, which governs IL-1β production. NLRP3 activation enhances antimicrobial defense, but excessive NLRP3 activity causes inflammatory tissue damage in conditions such as pulmonary fibrosis and acute respiratory di ...[more]