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Synthesis of Heteroannulated Indolopyrazines through Domino N-H Palladium-Catalyzed/Metal-Free Oxidative C-H Bond Activation.

ABSTRACT: A convenient approach to [1,2,5]oxadiazolo[3',4':5,6]pyrazino[2,3-b]indoles and their heteroannulated analogues bearing various aryl substituents in the backbone has been developed. This synthetic protocol is based on Pd-catalyzed Buchwald-Hartwig and subsequent annulation by intramolecular oxidative cyclodehydrogenation. The photophysical properties for new polycycles have been measured.

SUBMITTER: Kvashnin YA

PROVIDER: S-EPMC7331205 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Synthesis of Heteroannulated Indolopyrazines through Domino N-H Palladium-Catalyzed/Metal-Free Oxidative C-H Bond Activation.

Kvashnin Yuriy A YA Verbitskiy Egor V EV Zhilina Ekaterina F EF Rusinov Gennady L GL Chupakhin Oleg N ON Charushin Valery N VN

ACS omega 20200618 25

A convenient approach to [1,2,5]oxadiazolo[3',4':5,6]pyrazino[2,3-b]indoles and their heteroannulated analogues bearing various aryl substituents in the backbone has been developed. This synthetic protocol is based on Pd-catalyzed Buchwald-Hartwig and subsequent annulation by intramolecular oxidative cyclodehydrogenation. The photophysical properties for new polycycles have been measured. ...[more]

PMID: 32637843

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