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Genetic Polymorphism in TNF-?-308 G/A and TNF-? +252 A/G, as Prognostic Biomarker in Breast Cancer Patients among Indian Population.

ABSTRACT: BACKGROUND:Cytokines are the key regulator molecules that modulate immune response. Tumor necrosis factor (TNF- ?-308 G/A and TNF-? +252 A/G ) are inflammatory cytokine that control the progression of several types of cancer. They play a vital role in both tumor progression and destruction based on their concentrations. The role of TNF-?-308 G/A and TNF-? +252 A/G gene polymorphism in the etiology of breast cancer (BC) is not clearly understood. Therefore, present study investigates the association of TNF-? -308 G/A and TNF-? +252 A/G and the clinical features with Breast cancer patients. METHODS:In a case- control study, we have investigated 150 breast cancer patients and 300 age and ethnically matched healthy controls for duration of 3 years from North India. Promoter polymorphisms of tumor necrosis factor gene (TNF-? -308 G/A and TNF-? +252 A/G) were genotyped using allele specific oligonucleotide polymerase chain reaction ASO and restriction fragment length polymorphism (PCR-RFLP). The associations were evaluated by calculating the pooled odds ratio (OR) with 95% confidence interval (95% CI) using SPSS. RESULTS:Patients with different clinico-pathological variables and healthy controls were analyzed. Significant association was observed in A allele of TNF-? -308 G/A in breast cancer patients as compared to healthy controls (p<0.0001). However, no association was seen in TNF-? +252 A/G both at genotypic and allelic level. The GG genotype of TNF-? +252A/G is higher in grades III (p<0.01) patients. CONCLUSION:Our results suggest that TNF-?-308G/A polymorphism showed significant association with breast cancer patients.

SUBMITTER: Ahmad MM

PROVIDER: S-EPMC7332152 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Genetic Polymorphism in TNF-α-308 G/A and TNF-β +252 A/G, as Prognostic Biomarker in Breast Cancer Patients among Indian Population.

Ahmad Mohammad Margoob MM Parveen Farah F Akhter Naseem N Siddiqui Jamshaid Ahmad JA Shukla Nootan Kumar NK Husain Syed Akhtar SA

Asian Pacific journal of cancer prevention : APJCP 20200201 2

<h4>Background</h4>Cytokines are the key regulator molecules that modulate immune response. Tumor necrosis factor (TNF- α-308 G/A and TNF-β +252 A/G ) are inflammatory cytokine that control the progression of several types of cancer. They play a vital role in both tumor progression and destruction based on their concentrations. The role of TNF-α-308 G/A and TNF-β +252 A/G gene polymorphism in the etiology of breast cancer (BC) is not clearly understood. Therefore, present study investigates the ...[more]

PMID: 32102503

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Project description:Background and objectiveThe association between TNF-α -308 G/A polymorphism and COPD remains controversial due to insufficiently strict study designs and small group sizes among different studies. In the present study, a meta-analysis update which followed a stricter procedure was performed to obtain a clearer understanding of this association.MethodsA comprehensive database search was conducted to identify the case-control studies published up to July 2015 which reported an association between the TNF-α -308 G/A polymorphism and COPD risk. Data were extracted to calculate pooled odds ratios with 95% confidence intervals under the most appropriate genetic and allelic models. Sensitivity was analyzed, and heterogeneity as well as publication bias was assessed.ResultsThirty-eight eligible studies, comprising 3,951 COPD cases and 5,110 controls, were included in this study, among which 22 studies comprising 2,067 COPD cases and 2,167 controls were performed in Asians, and 16 studies comprising 1,884 COPD cases and 2,943 controls were in non-Asians. The overall result showed that TNF-α -308 G/A polymorphisms were significantly associated with increased COPD risk in both the codominant genetic and allelic models. Individuals with the GA or AA genotype were more susceptible to COPD development than those with the GG genotype. In addition, individuals with the AA genotype were more susceptible to developing COPD than those with the GA genotype. The subgroup analysis stratified by ethnicity supported the results in Asians but not in non-Asians. However, no association was found between TNF-α -308 G/A polymorphisms and COPD susceptibility either in Asians or in non-Asians in the meta-analysis conducted with restriction to former/current smokers.ConclusionThe present meta-analysis suggested that the TNF-α -308 G/A polymorphism was associated with an increased risk of COPD among Asians but not in non-Asians. Furthermore, individuals with the AA genotype of TNF-α -308 were more susceptible to developing COPD.

Dataset Information

Genetic Polymorphism in TNF-?-308 G/A and TNF-? +252 A/G, as Prognostic Biomarker in Breast Cancer Patients among Indian Population.

Publications

Genetic Polymorphism in TNF-α-308 G/A and TNF-β +252 A/G, as Prognostic Biomarker in Breast Cancer Patients among Indian Population.

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