Dataset Information
Association between -238 but not -308 polymorphism of Tumor necrosis factor alpha (TNF-alpha)v and unexplained recurrent spontaneous abortion (URSA) in Chinese population.
Ontology highlight
ABSTRACT: Objectives
TNF-alpha is a critical cytokine produced by Th1 cells while altered T helper 1 (Th1)-Th2 balance is found crucial for a successful pregnancy.Study design
A cohort of 132 Southern Chinese Han RSA patients and 152 controls constituted the subjects of this study. Two functional polymorphisms -308 and -238 of TNF-alpha were studied by association analysis.Results
lack of association was found in TNF-alpha -308 SNP yet a significant difference was discovered in -238 polymorphism.Conclusion
This study suggested that TNF-alpha may be a risk factor in Chinese RSA patients. However the ethnic differences may also contribute to the results.
SUBMITTER: Liu C
PROVIDER: S-EPMC2956720 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Publications
Association between -238 but not -308 polymorphism of Tumor necrosis factor alpha (TNF-alpha)v and unexplained recurrent spontaneous abortion (URSA) in Chinese population.
Reproductive biology and endocrinology : RB&E 20100928
<h4>Objectives</h4>TNF-alpha is a critical cytokine produced by Th1 cells while altered T helper 1 (Th1)-Th2 balance is found crucial for a successful pregnancy.<h4>Study design</h4>A cohort of 132 Southern Chinese Han RSA patients and 152 controls constituted the subjects of this study. Two functional polymorphisms -308 and -238 of TNF-alpha were studied by association analysis.<h4>Results</h4>lack of association was found in TNF-alpha -308 SNP yet a significant difference was discovered in -23 ...[more]