Ontology highlight
ABSTRACT:
SUBMITTER: Wan J
PROVIDER: S-EPMC7332464 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Wan Jinkai J Xing Shenghui S Ding Longfei L Wang Yongheng Y Gu Chenjian C Wu Yanling Y Rong Bowen B Li Cheng C Wang Siqing S Chen Kun K He Chenxi C Zhu Dandan D Yuan Songhua S Qiu Chengli C Zhao Chen C Nie Lei L Gao Zhangzhao Z Jiao Jingyu J Zhang Xiaoyan X Wang Xiangxi X Ying Tianlei T Wang Haibin H Xie Youhua Y Lu Yanan Y Xu Jianqing J Lan Fei F
Cell reports 20200703 3
Coronavirus disease 2019 (COVID-19) has become a worldwide threat to humans, and neutralizing antibodies have therapeutic potential. We have purified more than 1,000 memory B cells specific to SARS-CoV-2 S1 or its RBD (receptor binding domain) and obtain 729 paired heavy- and light-chain fragments. Among these, 178 antibodies test positive for antigen binding, and the majority of the top 17 binders with EC<sub>50</sub> below 1 nM are RBD binders. Furthermore, we identify 11 neutralizing antibodi ...[more]