Ontology highlight
ABSTRACT:
SUBMITTER: Klein DC
PROVIDER: S-EPMC7333739 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Klein David C DC Hainer Sarah J SJ
Current topics in developmental biology 20191230
In eukaryotes, DNA is highly compacted within the nucleus into a structure known as chromatin. Modulation of chromatin structure allows for precise regulation of gene expression, and thereby controls cell fate decisions. Specific chromatin organization is established and preserved by numerous factors to generate desired cellular outcomes. In embryonic stem (ES) cells, chromatin is precisely regulated to preserve their two defining characteristics: self-renewal and pluripotent state. This action ...[more]