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Visual Cortical Alterations and their Association with Negative Symptoms in Antipsychotic-Naive First Episode Psychosis.


ABSTRACT: Visual perceptual and processing deficits are common in schizophrenia and possibly point towards visual pathway alterations. However, no studies have examined visual cortical morphology in first-episode psychosis (FEP). In an antipsychotic-naïve FEP population, we investigated primary visual (V1), association area (V2), and motion perception (V5/MT) morphology compared to controls. We found reductions in the V1 and V2 areas, greater MT area and lower MT thickness in the FEP-schizophrenia group when compared to controls. Also, lower MT thickness was associated with worse negative symptoms. Our results shed light on this poorly studied area of visual cortex morphology in FEP.

SUBMITTER: Adhan I 

PROVIDER: S-EPMC7333935 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Visual Cortical Alterations and their Association with Negative Symptoms in Antipsychotic-Naïve First Episode Psychosis.

Adhan Iniya I   Lizano Paulo P   Bannai Deepthi D   Lutz Olivia O   Dhaliwal Kiranpreet K   Zeng Victor V   Miewald Jean J   Montrose Debra D   Keshavan Matcheri M  

Psychiatry research 20200416


Visual perceptual and processing deficits are common in schizophrenia and possibly point towards visual pathway alterations. However, no studies have examined visual cortical morphology in first-episode psychosis (FEP). In an antipsychotic-naïve FEP population, we investigated primary visual (V1), association area (V2), and motion perception (V5/MT) morphology compared to controls. We found reductions in the V1 and V2 areas, greater MT area and lower MT thickness in the FEP-schizophrenia group w  ...[more]

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