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No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis.


ABSTRACT: Cognitive impairment is an important predictor of disability in schizophrenia. Dopamine neurotransmission in cortical brain regions has been suggested to be of importance for higher-order cognitive processes. The aim of this study was to examine the relationship between extrastriatal dopamine D2-R availability and cognitive function, using positron emission tomography and the high-affinity D2-R radioligand [11C]FLB 457, in an antipsychotic-naive sample of 18 first-episode psychosis patients and 16 control subjects. We observed no significant associations between D2-R binding in the dorsolateral prefrontal cortex or hippocampus (β = 0.013-0.074, partial r = -0.037-0.273, p = 0.131-0.841). Instead, using Bayesian statistics, we found moderate support for the null hypothesis of no relationship (BFH0:H1 = 3.3-8.2). Theoretically, our findings may suggest a lack of detrimental effects of D2-R antagonist drugs on cognition in schizophrenia patients, in line with clinical observations.

SUBMITTER: Lee M 

PROVIDER: S-EPMC8455597 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis.

Lee Maria M   Fatouros-Bergman Helena H   Plavén-Sigray Pontus P   Ikonen Victorsson Pauliina P   Sellgren Carl M CM   Erhardt Sophie S   Flyckt Lena L   Farde Lars L   Cervenka Simon S  

NPJ schizophrenia 20210921 1


Cognitive impairment is an important predictor of disability in schizophrenia. Dopamine neurotransmission in cortical brain regions has been suggested to be of importance for higher-order cognitive processes. The aim of this study was to examine the relationship between extrastriatal dopamine D2-R availability and cognitive function, using positron emission tomography and the high-affinity D2-R radioligand [<sup>11</sup>C]FLB 457, in an antipsychotic-naive sample of 18 first-episode psychosis pa  ...[more]

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