Ontology highlight
ABSTRACT:
SUBMITTER: Petkovic M
PROVIDER: S-EPMC7335067 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Petkovic Maja M Oses-Prieto Juan J Burlingame Alma A Jan Lily Yeh LY Jan Yuh Nung YN
Nature communications 20200703 1
Communication between organelles is essential for their cellular homeostasis. Neurodegeneration reflects the declining ability of neurons to maintain cellular homeostasis over a lifetime, where the endolysosomal pathway plays a prominent role by regulating protein and lipid sorting and degradation. Here we report that TMEM16K, an endoplasmic reticulum lipid scramblase causative for spinocerebellar ataxia (SCAR10), is an interorganelle regulator of the endolysosomal pathway. We identify endosomal ...[more]