Proteomics

Dataset Information

0

TMEM16K is an interorganelle regulator of endosomal sorting.


ABSTRACT: Using proximity biotinylation proteomics based on TMEM16K/Ano10 (an endoplasmic reticulum lipid scramblase causative for spinocerebellar ataxia) BioID chimeras, we identify endosomal transport as a major functional cluster of interacting proteins.

INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

TISSUE(S): Permanent Cell Line Cell

SUBMITTER: Juan Oses-Prieto  

LAB HEAD: Alma L Burlingame

PROVIDER: PXD018990 | Pride | 2020-05-30

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
P20160302-09_FTMSms2hcd.RAW Raw
P20160310-03_FTMSms2hcd.RAW Raw
P20160310-07_FTMSms2hcd.RAW Raw
P20160310-08_FTMSms2hcd.RAW Raw
P20160310-09_FTMSms2hcd.RAW Raw
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Publications

TMEM16K is an interorganelle regulator of endosomal sorting.

Petkovic Maja M   Oses-Prieto Juan J   Burlingame Alma A   Jan Lily Yeh LY   Jan Yuh Nung YN  

Nature communications 20200703 1


Communication between organelles is essential for their cellular homeostasis. Neurodegeneration reflects the declining ability of neurons to maintain cellular homeostasis over a lifetime, where the endolysosomal pathway plays a prominent role by regulating protein and lipid sorting and degradation. Here we report that TMEM16K, an endoplasmic reticulum lipid scramblase causative for spinocerebellar ataxia (SCAR10), is an interorganelle regulator of the endolysosomal pathway. We identify endosomal  ...[more]

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