Ontology highlight
ABSTRACT:
SUBMITTER: Malone RW
PROVIDER: S-EPMC7336703 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Malone Robert W RW Tisdall Philip P Fremont-Smith Philip P Liu Yongfeng Y Huang Xi-Ping XP White Kris M KM Miorin Lisa L Del Olmo Elena Moreno EM Alon Assaf A Delaforge Elise E Hennecker Christopher D CD Wang Guanyu G Pottel Joshua J Smith Nora N Hall Julie M JM Shapiro Gideon G Mittermaier Anthony A Kruse Andrew C AC García-Sastre Adolfo A Roth Bryan L BL Glasspool-Malone Jill J Ricke Darrell O DO
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SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19 differ from common acute viral diseases. Currently, there are no pre- or post-exposure prophylactic COVID-19 medical countermeasures. Clinical data suggest that famotidine may mitigate COVID-19 disease, but both mechanism of action and rationale for dose selection remain obscure. We explore several plausible avenues of activity including antiviral and host-mediated actions. We propose that the principal famoti ...[more]