Ontology highlight
ABSTRACT:
SUBMITTER: Gnanasundram SV
PROVIDER: S-EPMC7337897 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Gnanasundram Sivakumar Vadivel SV Malbert-Colas Laurence L Chen Sa S Fusée Leila L Daskalogianni Chrysoula C Muller Petr P Salomao Norman N Fåhraeus Robin R
Nucleic acids research 20200701 12
Cell growth requires a high level of protein synthesis and oncogenic pathways stimulate cell proliferation and ribosome biogenesis. Less is known about how cells respond to dysfunctional mRNA translation and how this feeds back into growth regulatory pathways. The Epstein-Barr virus (EBV)-encoded EBNA1 causes mRNA translation stress in cis that activates PI3Kδ. This leads to the stabilization of MDM2, induces MDM2's binding to the E2F1 mRNA and promotes E2F1 translation. The MDM2 serine 166 regu ...[more]