Ontology highlight
ABSTRACT:
SUBMITTER: Dan X
PROVIDER: S-EPMC7337932 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Nucleic acids research 20200701 12
Mitochondria are vital for cellular energy supply and intracellular signaling after stress. Here, we aimed to investigate how mitochondria respond to acute DNA damage with respect to mitophagy, which is an important mitochondrial quality control process. Our results show that mitophagy increases after DNA damage in primary fibroblasts, murine neurons and Caenorhabditis elegans neurons. Our results indicate that modulation of mitophagy after DNA damage is independent of the type of DNA damage sti ...[more]