Ontology highlight
ABSTRACT:
SUBMITTER: Yu HP
PROVIDER: S-EPMC4415581 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Scientific reports 20150430
Previous study revealed that the protective effect of TIGAR in cell survival is mediated through the increase in PPP (pentose phosphate pathway) flux. However, it remains unexplored if TIGAR plays an important role in DNA damage and repair. This study investigated the role of TIGAR in DNA damage response (DDR) induced by genotoxic drugs and hypoxia in tumor cells. Results showed that TIGAR was increased and relocated to the nucleus after epirubicin or hypoxia treatment in cancer cells. Knockdown ...[more]