Ontology highlight
ABSTRACT:
SUBMITTER: Shang Y
PROVIDER: S-EPMC7337969 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Nucleic acids research 20200701 12
Repair of DNA double-strand breaks (DSBs) with homologous chromosomes is a hallmark of meiosis that is mediated by recombination 'bridges' between homolog axes. This process requires cooperation of DMC1 and RAD51 to promote homology search and strand exchange. The mechanism(s) regulating DMC1/RAD51-ssDNA nucleoprotein filament and the components of 'bridges' remain to be investigated. Here we show that MEIOK21 is a newly identified component of meiotic recombination bridges and is required for e ...[more]