Ontology highlight
ABSTRACT:
SUBMITTER: Rosenbauer J
PROVIDER: S-EPMC7340325 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Rosenbauer Jakob J Zhang Chengting C Mattes Benjamin B Reinartz Ines I Wedgwood Kyle K Schindler Simone S Sinner Claude C Scholpp Steffen S Schug Alexander A
PLoS computational biology 20200624 6
During embryogenesis, morphogens form a concentration gradient in responsive tissue, which is then translated into a spatial cellular pattern. The mechanisms by which morphogens spread through a tissue to establish such a morphogenetic field remain elusive. Here, we investigate by mutually complementary simulations and in vivo experiments how Wnt morphogen transport by cytonemes differs from typically assumed diffusion-based transport for patterning of highly dynamic tissue such as the neural pl ...[more]