TNF-? G-308A genetic variants, serum CRP-hs concentration and DNA damage in obese women.
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ABSTRACT:
SUBMITTER: Wlodarczyk M
PROVIDER: S-EPMC7340642 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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TNF-α G-308A genetic variants, serum CRP-hs concentration and DNA damage in obese women.
Włodarczyk Marta M Ciebiera Michał M Nowicka Grażyna G
Molecular biology reports 20190321 2
Obesity is associated with inflammation, which can disturb genome stability. Tumor necrosis factor (TNF-α) polymorphism was found to affect TNF-α protein production and inflammation. Therefore, the present study illustrates the relationship between TNF-α polymorphism, the degree of inflammation assessed by serum high sensitivity C-reactive protein concentration (CRP-hs) and basal DNA damage in patients with obesity (BMI 30-34.9 kg/m<sup>2</sup>) and control subjects with proper body mass (BMI < ...[more]
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